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The EMBO Journal
3 天
Neural precursor cells rescue symptoms of Rett syndrome by activation of the Interferon γ ...
To address the unmet need for a cure for RTT, the therapeutic potential of adult Neural Precursor Cells (NPCs) was ...
The EMBO Journal
4 天
Liver protects neuron viability and electrocortical activity in post-cardiac arrest brain ...
The liver function in post-cardiac arrest brain injury is not known and was investigated in a pig model of global cerebral ...
The EMBO Journal
4 天
Astrocyte allocation during brain development is controlled by Tcf4-mediated fate restriction
Astrocytes in the brain exhibit significant regional diversity, but the mechanisms controlling their heterogeneity remain ...
The EMBO Journal
5 天
Acetylation of TIR domains in the TLR4-Mal-MyD88 complex regulates immune responses in sepsis
Activation of macrophage TLR4 by bacterial endotoxins is important for the progression of sepsis, but the underlying ...
The EMBO Journal
5 天
Reduction of chromosomal instability and inflammation is a common aspect of adaptation to ...
RPE-1 cells adapt to aneuploidy in vitro, a process characterized by reduced CIN and inflammation. This study shows that this ...
The EMBO Journal
3 天
TBK1-Zyxin signaling controls tumor-associated macrophage recruitment to mitigate antitumor ...
Although the role of innate immune sensing pathways is well-studied in the pathogenesis of malignancies, whether they ...
The EMBO Journal
4 天
A shorter splicing isoform antagonizes ZBP1 to modulate cell death and inflammatory responses
Mice express full-length protein ZBP1-L as well as an alternatively-spliced shorter isoform (ZBP1-S) containing only its two ...
The EMBO Journal
7 天
IF1 is a cold-regulated switch of ATP synthase hydrolytic activity to support thermogenesis ...
How the hydrolytic activity of mitochondrial ATP synthase is modulated during brown adipose tissue (BAT) thermogenesis ...
The EMBO Journal
12 天
CaMKII suppresses proteotoxicity by phosphorylating BAG3 in response to proteasomal dysfunction
CaMKII activates the HRI/eIF2α signaling pathway and inhibits the proteotoxicity induced by proteasome inhibition through ...
The EMBO Journal
10 天
Glutaminolysis provides nucleotides and amino acids to regulate osteoclast differentiation ...
Metabolic rewiring is essential for osteoclast differentiation and bone resorption. This study shows that glutaminolysis ...
The EMBO Journal
7 天
RNF144B negatively regulates antiviral immunity by targeting MDA5 for autophagic degradation
MDA5 is a critical cytoplasmic RNA sensor capable of triggering type I interferon pathways. This study shows that the E3 ...
The EMBO Journal
7 天
RNA fine-tunes estrogen receptor-alpha binding on low-affinity DNA motifs for ...
RNA modulates transcription factor binding to DNA, though the subsequent effect on transcription remains unclear. The study ...
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