The EMBO Journal9 小时
APOE from astrocytes restores Alzheimer’s Aβ-pathology and DAM-like responses in APOE ...
In the early phase of Alzheimer’s disease, astrocytes are the primary source of APOE in the brain. This study examined the ...
The EMBO Journal1 天
The winter holidays are glorious—except when they’re not
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and ...
The EMBO Journal1 天
Circadian rhythms of macrophages are altered by the acidic tumor microenvironment
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Tumor-associated macrophages (TAMs) are prime ...
The EMBO Journal2 天
Glutamine sensing licenses cholesterol synthesis
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The mevalonate pathway produces essential ...
The EMBO Journal7 天
Rett syndrome: interferon-γ to the rescue?
In conclusion, this intriguing report builds on the work of many other groups by further unraveling MECP2 function in the ...
The EMBO Journal10 天
TRPC5: a new entry to the chromaffin cell’s palette of ion channels that control adrenal ...
Hypoglycemia is an extremely common side effect of insulin therapy experienced mainly by patients with type 1 diabetes ...
The EMBO Journal12 天
Brain mitophagy in space and time
A new resource by Rappe et al (2024) now provides a spatiotemporal landscape of mitophagy changes during mouse brain aging at ...
The EMBO Journal3 天
Hair follicle stem cells and the collapse of self-tolerance in alopecia: the interplay of ...
The hair follicle is thought to be a site of ‘immune privilege,’ or relative protection from autoimmune and inflammatory responses. In particular, the long-lived, quiescent hair follicle stem cells ...
The EMBO Journal15 天
Deep quantification of substrate turnover defines protease subsite cooperativity
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Substrate specificity determines protease ...
The EMBO Journal19 天
Cyclophilin D plays a critical role in the survival of senescent cells
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Senescent cells present an excessive flux of ...
The EMBO Journal6 天
Making contact away from home: a bacterial secreted effector mediates inter-organelle ...
Inter-organelle communication via the formation of membrane contact sites (MCS) is essential for cell homeostasis. Bacterial pathogens residing in membrane bound vacuoles have exploited this ...
The EMBO Journal18 天
Transport mechanism of DgoT, a bacterial homolog of SLC17 organic anion transporters
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The solute carrier 17 (SLC17) family contains ...