The San Francisco 49ers are set to host the Detroit Lions at Levi's Stadium in Santa Clara, California, on Monday, December ...

San Francisco 49ers RB Isaac Guerendo was dealing with a hamstring injury. Here are the latest updates leading up to ...

Head coach Kyle Shanahan offered an update on Saturday regarding the recovery of San Francisco 49ers wide receiver Brandon ...

The 49ers are set to head into their "Monday Night Football" contest with the Detroit Lions a little worse for the wear, ...

The Lions are holding out hope that running back David Montgomery will be able to play again this season, but his return will not come against the 49ers ...

San Francisco 49ers head coach Kyle Shanahan spoke with reporters after Saturday's practice as the team prepares for its Week ...

The 49ers will have running back Isaac Guerendo for Monday Night Football. Guerendo, who missed last week's game with a ...

The San Francisco 49ers are preparing for their Week 17 contest against the Detroit Lions on Monday at Levi's Stadium in ...

The NFL has handed down fines to multiple San Francisco 49ers players for their actions during last weekend's game against the Miami Dolphins, per ...

The San Francisco 49ers entered Sunday's matchup against the Miami Dolphins without two key offensive contributors: running ...

The NFL's much-discussed new rule against hip-drop tackles has only produced one penalty flag this season, against Carolina's ...

San Francisco 49ers head coach Kyle Shanahan addressed reporters on Saturday following the team's final practice before their ...