Following a lengthy holdout during training camp, Brandon Aiyuk signed a four-year, $120 million contract with the San Francisco 49ers in late August. After landing his new deal, Aiyuk and the 49ers ...

San Francisco 49ers wide receiver Brandon Aiyuk had to be carted to the locker room during the 49ers' Week 7 game against the Kansas City Chiefs. The wideout had made his second catch of the game ...

San Francisco 49ers wide receiver Brandon Aiyuk was outstanding last season. Despite sharing targets with George Kittle and ...

A rough season for Brandon Aiyuk just got worse. The star San Francisco 49ers receiver, who held out until getting a $120 million extension before the start of the season, was carted off with a ...

San Francisco 49ers star Brandon Aiyuk revealed the full extent of his gruesome knee injury in a YouTube video on Monday night, one week after his injury.

SANTA CLARA — The 49ers’ worst suspicions were confirmed Monday when it was learned Brandon Aiyuk was lost for the season with a serious knee injury. Coach Kyle Shanahan confirmed during a ...

Christian McCaffrey wasn't eased back into action when he made his return to the field on Sunday afternoon against the ...

Christian McCaffrey is set to make his season debut for the San Francisco against the Tampa Bay Buccaneers on Sunday. How ...

We knew San Francisco 49ers star Brandon Aiyuk wouldn’t play again this season after suffering a major knee injury in the Super Bowl rematch against the Chiefs. But now, we know just how ...

The 49ers and wide receiver Brandon Aiyuk got the worst news on his injured right knee. According to a report from Fox Sports’ Jordan Schultz, tests confirmed the 49ers’ leading receiver from ...

The last time star wide receiver Brandon Aiyuk and the San Francisco 49ers took on the Kansas City Chiefs, it did not go swimmingly. It was no better on Sunday.

The San Francisco 49ers earned a massive win in Week 8 against the Dallas Cowboys and now could be in the market to add.